Yes, I am running a piggyback - Greddy Ultimate tuned by Kenny Tran for 89 Octane 10% ethanol blend for 228.4WHP. I went for a safe street tune.
If you run a stand alone on a late model Scion/Toyo, then you will not be able to replace the ECM together. There are too many modules and systems tied to it like the ABS, SRS, Air Climate, Cluster Gauges, TPWS, MIL, DTC3, charging, etc. If your going to be in full race trim, then you can wire to bypass these systems. The NittotC was originally built with a standalone (AEM I think) that was fully integrated with the ECM. Either way can be done. You just have to plane accordingly.
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How Fast Was I Going? 
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